Whom portrays Mrs. Wheeler Wheeler? Which actress assumes the role of Karen Wheeler in the series? Who is the performer behind Karen Wheeler? Karen is portrayed by whom? Which actor acts as the character of Karen Wheeler on the show? Who is the talent personifying Karen the mother's character to life? Which actress takes on the role of Karen Wheeler in the series? Whoever takes on the part of Karen Wheeler? Who is the talented individual portraying Karen the mother on the series? What actor embodies the character of Karen Wheeler to the screen?